Provide services as a Bioinformatician (Stem Cell Translation Laboratory Support) in support of the overall functions of the National Center for Advancing Translational Sciences (NCATS) within the National Institutes of Health (NIH). The ideal candidate will have experience with preprocessing tools for alignment, counting or sequence analysis (e.g., Cell Ranger, STAR, salmon, GATK) and R packages designed for the above-mentioned methods (e.g., DESeq2, Seurat).

Duties and Responsibilities:

• Serve as bioinformatics expert and coordinate with teams of biologists to conduct experimental queries and/or perform portions of studies using complex procedures and techniques common to modern bioinformatics. 1
• Coordinate building bioinformatics infrastructure to ensure easy and meaningful scientific analysis and interpretation of data.
• Provide broad-based programming and analytic support for a wide variety of bioinformatic and research projects. 2
• Perform computational analysis of, and interpret results. 3
• Provide reports based on analysis of scientific data. 4
• Perform sequencing and alignment of raw data, and interpret new data using larger public access datasets. 5
• Provide interpretive analyses of data derived from different experimental platforms to generate biological meaning.
• Write custom programs and algorithms to support data analyses and discovery.
• Collaborate with scientists to design, analyze, manage and interpret all types of data.
• Work with staff on planning of experiments, and data analysis for internal and collaborative projects; use bioinformatics expertise to advise and help bench scientists on experimental design and trouble-shooting.
• Work with staff to develop specifications for new analysis; design, test and implement solutions.
• Maintain proper and detailed documentation of the analysis performed and report results at lab meetings.
• Attend scientific and programming meetings; take and compile comprehensive notes; organize and edit content of meeting reports.
• Prepare scientific reports and progress reports; assemble data to prepare tables, graphs and slides; conduct scientific and program related information searches and report results.
• Devise novel methods of statistical analysis for collected data.
• Utilize and adapt existing bioinformatics techniques to check for trends and patterns in the data. Perform data processing and data analysis with existing computational and statistical methods. Assist in evaluating and interpreting results for validity and scientific meaning.
• Develop and optimize programs and scripts that facilitate organization, integration and data-mining of large data sets; integrate these models into a framework of best practices.
• Participate in the design of new protocols involving computational methods.
• Work with staff on the development and maintenance of bioinformatics tools, scripts and pipe-lines for data.
• Participate in research design with investigators for determining best practices pertaining to the bioinformatics analysis in new and ongoing projects.
• Research and review literature to retrieve targeted clinical or scientific information, including novel statistical methods, from publicly available resources.
• Collaborate with experimentalists and computational biologists to develop new computational tools to answer research questions of interest.
• Provide training in and technical support (including product updates and version control) for programs, algorithms, archives, and pipelines generated during the course of this work.
• Instruct staff in computational analysis of data.
• Provide ad hoc trainings and hands-on workshops on the use of bioinformatics tools.
• Provide training of students, new investigators, and other laboratory personnel in the use of techniques, procedures and equipment to complete the objectives of the laboratory.
• Work with an interdisciplinary team to apply computational data analysis approaches to make biological discoveries. Collaborate with group members in experiments associated with data collection.
• Collaborate with biologists, statisticians and/or other bioinformaticians in the design of models summarizing/explaining experimental data.
• Attend group meetings; present findings; author publications resulting from projects.
• Present analysis results at research conferences and meetings. Present new research data in group settings, at meetings or seminars. Present scientific and technical data at scientific conferences.
• Run Validation - Ad-Hoc
• Meet with lab members to present updates - Daily

Basic Qualifications:

• Ph.D. or M.S. required.
• Skilled in R, GTAK, Salmon, Python, MATLAB, Linux, and Bash.
• Expertise in next gen sequencing data analysis: Bulk RNA-Sequencing, clinical and/or translational research, genome-wide association studies, single Cell RNA, sequencing, working with large data sets, whole genome sequencing, whole exome sequencing, cloud-based computing, pipeline development, multi-omics analysis, data quality control, sequence alignment, machine learning, ATAC-sequencing , and ChIP-Sequencing.

Minimum Qualifications:

• Preferred qualifications include experience with next-generation sequencing methods on Illumina and 10x Genomics platforms. Experience with other Genomics — such as WES, WGS and targeted sequencing methods — are a plus.
• A solid understanding of clustering and dimensionality reduction techniques for big genomic datasets, experience with Python programming, and familiarity with Linux BASH scripting, which is necessary for proper utilization of NIH’s high-performance computing capabilities, are preferred.
• Ability to multi-task and pay close attention to detail.
• Excellent analytical, organizational and time management skills.
• Strong communication skills, both oral and written.

• This job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required by this position.

To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

GAP Solutions provides reasonable accommodations to qualified individuals with disabilities. If you need an accommodation to apply for a job us at recruiting@gapsi.com. You will need to reference the requisition number of the position in which you are interested. Your message will be routed to the appropriate recruiter who will assist you. Please note, this email address is only to be used for those individuals who need an accommodation to apply for a job. Emails for any other reason or those that do not include a requisition number will not be returned.